Induction of sister-chromatid exchange in human lymphocytes by vitamin B6

Mutat Res. 1983 Nov;124(2):175-8. doi: 10.1016/0165-1218(83)90177-5.

Abstract

Vitamin B6, or pyridoxine hydrochloride, enhanced sister-chromatid exchange (SCE) rates in cultured normal human lymphocytes. No increase was found in SCE frequency when lymphocytes were treated with pyridoxal-5-phosphate (P-5-P) or 4-pyridoxic acid (4-PA) to which vitamin B6 is finally converted.

MeSH terms

  • Cells, Cultured
  • Crossing Over, Genetic / drug effects*
  • Humans
  • Lymphocytes / drug effects*
  • Pyridoxal Phosphate / toxicity
  • Pyridoxic Acid / toxicity
  • Pyridoxine / toxicity*
  • Sister Chromatid Exchange / drug effects*

Substances

  • Pyridoxic Acid
  • Pyridoxal Phosphate
  • Pyridoxine